The 33-year-old actress took to Instagram on Monday evening to share her plan with her 27.4 million followers.
In a video, she said: “How would you feel about having dinner with me? Virtually.
“12 lucky people will join me, virtually, and we’re going to put together a store cupboard dinner.
“Together we’ll cook it and we’ll eat it together and we’ll discuss lots of things, isolation, fear and also funny videos and the fact that I can’t really cook.
“So it’s going to be fun, it’ll be interesting.”
Emilia then explained more about the SameYou Covid-19 relief fund she wants to raise £250,000 for.
She wrote in the caption alongside the video: “Dearest ones, from my isolation booth I write to you with a plea for help!
“Due to the current frightening and ever changing coronavirus emergency please would you help me raise £250,000, by donating through the link in my Bio, to provide stroke and brain injury patients with essential support!!
“This fund will also help in freeing up the hospital beds needed to deal with the pandemic, to care for those who also need a space to heal.
“100% of your generosity will fund virtual rehab clinic support in the coming weeks… a very big task and a very big ask but you are all very big hearted souls so I know you’ll want to help me help them! @sameyouorg.”
Emilia founded SameYou in March last year after suffering two brain aneurysms during her early days on Game of Thrones, where she played Daenerys Targaryen.